Pubblicazioni scientifiche

Extent of chromosomal mosaicism influences the clinical outcome of in vitro fertilization treatments
Objective: To assess whether the extent of chromosomal mosaicism can influence the success rate of IVF treatments.

Genetic diseases and aneuploidies can be detected with a single blastocyst biopsy: a successful clinical approach
STUDY QUESTION: Can simultaneous detection of aneuploidies and genetic diseases or chromosomal aberrations in blastocysts reduce the chance of ...

Current experience concerning mosaic embryos diagnosed during preimplantation genetic screening
The concept of embryos containing multiple cell lines (mosaicism) is not new, but much attention has been paid to this concept recently owing to recent advances in molecular techniques to analyze human embryos. Mosaicism in embryos has been known and...

Validation of a semiconductor next-generation sequencing-based protocol for preimplantation genetic diagnosis of reciprocal translocations
Autori: S. Bono, A. Biricik, L. Spizzichino, A. Nuccitelli, M. G. Minasi, E. Greco, F. Spinella and F. Fiorentino Objective We aim to validate a semiconductor next-generation sequencing (NGS)-based method to detect ...

Application of next-generation sequencing technology for comprehensive aneuploidy screening of blastocysts in clinical preimplantation genetic screening cycles
  Abstract STUDY QUESTION: Can next-generation sequencing (NGS) techniques be used reliably for comprehensive aneuploidy screening of human embryos ...

Comparative genomic hybridization selection of blastocysts for repeated implantation failure treatment: a pilot study
Abstract The aim of this study is to determine if the use of preimplantation genetic screening (PGS) by array comparative genomic hybridization (array CGH) and transfer of a single euploid blastocyst in patients with ...

Development and validation of a next-generation sequencing-based protocol for 24-chromosome aneuploidy screening of embryos
Abstract OBJECTIVE: To validate a next-generation sequencing (NGS)-based method for 24-chromosome aneuploidy screening and to investigate its applicability to ...

Referee Commentaries: Use of prenatal chromosomal microarray: prospective cohort study and systematic review and metaanalysis.

Reply: Questions about the accuracy of polar body analysis for preimplantation genetic screening.

Molecular Genetics Techniques for Preimplantation Genetic Diagnosis

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